HORDB

ID: hor001621
Uniprot ID: Q9HCQ7
Protein name: Neuropeptide NPSF
Gene name: NPVF
Organism: Homo sapiens (Human)
Family: FARP (FMRFamide related peptide) family
Source: Human
Expression: Isoform 1 is specifically expressed in the retina. Neuropeptides RFRP-1 and NPVF are detected in the hypothalamus.
Disease: Diseases associated with NPVF include Precocious Puberty, Central, 1.
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005102 signaling receptor binding; GO:0005515 protein binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0032277 negative regulation of gonadotropin secretion
GO CC: GO:0005576 extracellular region

Sequence: SLNFEELKDWGPKNVIKMSTPAVNKMPHSFANLPLRF
Length: 37(56-92)
Propeptide: MEIISSKLFILLTLATSSLLTSNIFCADELVMSNLHSKENYDKYSEPRGYPKGERSLNFEELKDWGPKNVIKMSTPAVNKMPHSFANLPLRFGRNVQEERSAGATANLPLRSGRNMEVSLVRRVPNLPQRFGRTTTAKSVCRMLSDLCQGSMHSPCANDLFYSMTCQHQEIQNPDQKQSRRLLFKKIDDAELKQEK
Signal peptide: MEIISSKLFILLTLATSSLLTSNIFC
Modification: T37 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001621_AF2.pdb

hor001621_ESM.pdb

Mass:	490027	Formula:	C195H303N51O52S2
Absent amino acids:	CQY	Common amino acids:	KLNP
pI:	10.33	Basic residues:	6
Polar residues:	9	Hydrophobic residues:	13
Hydrophobicity:	-39.73	Boman Index:	-5024
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	73.78
Instability Index:	7047.57	Extinction Coefficient cystines:	5500
Absorbance 280nm:	152.78